The Cottagers played at the national stadium in 2018 as they beat Aston Villa 1-0 to reach the Premier League, only to be relegated 12 months later.
Captain Tom Cairney and star striker Aleksandar Mitrovic are still with the squad, and there are nine members of that 2018 team still within Fulham’s ranks.
That experience could be crucial as Scott Parker’s men try to win the richest game in football, with Fulham priced at 53/20 to grab the win.
Whoever wins Tuesday’s battle should earn around £160million in the process and this year’s final promises to be a cracker.
Expect Goals in London
These two West London rivals have entertained fans since the resumption of the Championship, but both narrowly missed out on automatic promotion.
Leeds United went up as champions, while West Bromwich Albion did enough on the final day to secure second.
Fulham are looking for an immediate return to the top flight, while Brentford are trying to break their playoff hoodoo.
If the Bees fail to win, they will have taken part in more unsuccessful playoff campaigns in the English Football League than any other club, with this their ninth try.
While both of this year’s league meetings featured less than 2.5 goals, a more entertaining encounter is expected at Wembley on Tuesday.
Fulham have scored nine goals in their last four games, while Brentford have netted five times from their last five outings.
Over 2.5 goals is priced at 13/10 and, with no crowd, the players should be less nervous on the hallowed Wembley turf.
Talismen to Come to the Fore
Like all good Championship teams, Brentford and Fulham have heavily relied on key players for their goals.
Brentford’s Said Benrahma has been directly involved in all three goals against Fulham this season, and he is 17/2 to score first at Wembley.
Fulham’s Mitrovic and Brentford’s Ollie Watkins have also been in inspired form this season, scoring 26 and 25 times respectively in the regular season
Mitrovic is 37/20 to score anytime, while Watkins can be backed at 6/4 in the same market.
Mitrovic should overcome injury to start and it promises to be an end-to-end battle between these two clubs.
Whoever loses faces another gruelling 46-game campaign in the Championship next season, and the prospect of losing their key players.
England’s big clubs are already sniffing around both squads and Fulham will feel that their “big-game experience” should be enough as they try to add to Brentford’s playoff woes.
*All odds correct at time of writing