City’s return to top-flight football was a relatively comfortable one as they recorded a 3-0 home victory over Arsenal, who had defender David Luiz sent off and were second best for the majority of the match.
Raheem Sterling, Kevin De Bruyne and Phil Foden, who could be handed a start as Pep Guardiola looks to rotate his squad, all got on the scoresheet at the Etihad as City cemented their position in second.
Victory on Monday would move the Citizens to within 20 points of table-toppers Liverpool, who would have to endure a catastrophic end-of-season collapse to not win their first Premier League title.
City have won all five home games against Burnley under Guardiola in both league and cup, scoring 19 goals and conceding just two, while they have scored in 33 of their past 34 league matches at the Etihad.
The Citizens have won the last four meetings against the Clarets, three of which they kept clean sheets in, and the hosts are 4/7 to win to zero this evening.
Argentina international Sergio Aguero, who could be given a start after only coming off the bench last time out, has scored nine goals in nine appearances against Burnley in all competitions – including in all five home games – and he is 2/1 to score first.
Defender Eric Garcia will not be involved in this clash after suffering a concussion against Arsenal in midweek, while fellow defender John Stones will be assessed after sustaining an ankle injury during training.
As for Burnley, they are the joint-fifth lowest scorers in the division this season, having netted just 34 times, and they will be without their two leading strikers for the contest
Ashley Barnes is still recovering from hernia surgery while fellow forward Chris Wood, who leads the club’s scoring charts with 11 this term, misses out with an Achilles injury.
It is hard to see where the goals are going to come from and the Clarets, who are winless in 15 away league visits to City since a 5-2 victory in March 1963, are set for a tough evening.
Burnley’s only win in the past 23 meetings in all competitions was a 1-0 victory at home in the league in March 2015 and, if you are feeling brave, the same result can be backed at 46/1.
Sean Dyche will also be without winger Johann Berg Gudmundsson, who is struggling with a calf problem, but he will have highly-rated Dwight McNeil to call upon.
The 20-year-old has scored twice and registered five assists in the league this season and he is 10/1 to score anytime, while it is a massive 33/1 for him to net the first or last goal.
On a positive note, Burnley are unbeaten in their last seven league games, their longest run since an eight-game streak 13 months ago, while they could become just the fourth team to win away at both Manchester clubs in a Premier League season.
City are the firm 1/8 favourites to pick up the win, while a draw is priced at 8/1 and Burnley are huge 19/1 outsiders to claim the spoils.
*All odds correct at time of writing