The Bills are 4-1 so far this season, and they sit top of the AFC East, with the New England Patriots, New York Jets and Miami Dolphins all struggling.
At present, the Titans sit top of the AFC South, but their record of 3-2 suggests they have not been as prolific as the Bills this season.
Bills Can Make it Five in a Row
This Monday, Sean McDermott’s men can make it five wins in a row after beating Miami Dolphins, Washington Football Team, Houston Texans, and Kansas City Chiefs in recent weeks.
The Titans have won three of their last four, but their defeat to the Jets shows they are far from the finished product.
While they will take confidence from their 42-16 victory over Buffalo in 2020, that was their first win over the Bills in the last four meetings.
The Bills are 20/21 to cover the -6.5 handicap result, and it looks a sensible bet, with the Bills able to cover that handicap in their last four games.
Allen to Lead the Way Once Again
Bills QB Josh Allen is one of the shining stars in the NFL, and he guided them to the playoffs last season.
Allen is a dual-threat QB, meaning defences have to be wary of his arm, as well his running attack. He led the Bills in passing and rushing yards last week against the Chiefs and helped them score four touchdowns in the process.
The former Wyoming quarterback is difficult to stop, and it would come as no surprise to see him throw for over 292.5 yards, at odds of 4/5.
NFL Fans in for a Treat on Monday night
There have already been some thrilling games this weekend in the NFL, with the Jacksonville Jaguars beating Miami Dolphins with seconds to go.
Baltimore Ravens, Green Bay Packers, Arizona Cardinals and the Dallas Cowboys all picked up eye-catching wins in the last few days, and the Titans and Bills could play out a thriller in Nashville.
The Bills have scored over 35 points in every one of their last four games, while the Titans have Derrick Henry at their disposal.
He can cause chaos single-handedly for any defence, and there’s every chance there are more than 53 points scored at 10/11 on Monday night.
*All odds correct at time of writing